| 茴拉西坦治疗血管性痴呆的双盲临床试验 |
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| 引用本文： | 洪震,丁兆兰,蒋雨平,俞丽云,翟治平. 茴拉西坦治疗血管性痴呆的双盲临床试验[J]. 中国新药与临床杂志, 1994, 0(3) |
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| 作者姓名： | 洪震 丁兆兰 蒋雨平 俞丽云 翟治平 |
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| 作者单位： | 上海医科大学神经病学研究所 |
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| 摘 要： | 血管性痴呆６０例（男性５０例，女性１０例；年龄５８±ｓ７ａ）用茴拉西坦作双盲对照观察。治疗组和对照组（安慰剂）各３０例，治疗组服茴拉西坦２００ｍｇ，ｔｉｄ，共８ＷＫ结果：临床总有效率，治疗组８３％，对照组６０％（Ｐ＜０．０５）；治疗组记忆商由６９±１５增至８４±１７（Ｐ＜０．０１），对照组由７４±１６增至８０±２０（Ｐ＞０．０５）。不良反应较轻，使用安全，可以选用。
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| 关 键 词： | 茴拉西坦，血管性痴呆，精神状态判断表，双盲法 |
Double-blind clinical trial of aniracetam in treating vasculay dementia |
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| HONGZhen,DING Zhao-Lan,JIANG Yu-Ping,YU Li-Yun,QU Zhi-Ping. Double-blind clinical trial of aniracetam in treating vasculay dementia[J]. Chinese Journal of New Drugs and Clinical Remedies, 1994, 0(3) |
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| Authors: | HONGZhen DING Zhao-Lan JIANG Yu-Ping YU Li-Yun QU Zhi-Ping |
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| Abstract: | A double-blind trial of aniracetam in therapy of vascular dementia was conducted on 60 patients(M 50,F10;age 58±s 7 a),who were equally divided into treated group and control group.The aniracetam dosage was 200 mg,po,tid,for 8 wk.The total response rate of treated group was 83%,that of the control(placebo) group 60%(P<0.05).The memory quotient of treated group increased from 69± 15 to 84± 17(P<0.01),that of the control group increased from 74± 16 to 80± 20(P>0.05).Adverse reactions were mild and so it is safe to select this drug for clinical use in vascular dementia. |
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| Keywords: | aniracetam vascular dementia psychiatric status rating scales double-blind method |
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