重症中暑院前地塞米松干预疗效研究

目的分析重症中暑患者院前地塞米松干预的疗效及对预后影响。方法重症中暑患者47例,均给予降温,吸氧,补液,纠正水、电解质、酸碱平衡紊乱和预防感染等治疗。根据有无院前地塞米松干预将47例重症中暑患者分为两组:地塞米松组21例和对照组26例。比较两组的临床症状、体征及实验室检测指标。结果地塞米松组昏迷程度、部分凝血活酶时间(APTT)、死亡与对照组比较,均有统计学差异(p<0.05)。结论重症中暑患者院前地塞米松干预能改善凝血功能、降低死亡率,可能是重症中暑患者重要治疗手段。

STUDY OF THE EFFECT OF THE DEXAMETHASONE PRE-HOSPITAL TREATMENT ON 47 CASES SEVERE HEATSTROKE YOUTH AND MIDDLE-AGED PATIENTS

Objective To assess the value of dexamethasone pre-hospital treatment for severe heatstroke patients and the effect on the prognosis. Method Forty-seven severe heatstroke patients were enrolled. They were all treated with cooling, oxygen, fluid replacement, infection prevention, correcting the disturbance of water, electrolytes and acid-base balance etc. They were divided into 2 groups by whether received dexamethasone pre-hospital treatment, 21 cases in dexamethasone group and 26 cases in controlled group. The clinical symptoms, signs and laboratory examinations of two groups were compared. Result The difference of the degree of coma, the partial thromboplastin time, the death rate between two groups were significantly (p< 0.05). Conclusion Dexamethasone pre-hospital treatment can ameliorate the coagulation function and decrease the death rate of severe heatstroke patients. It is probably one important means of treating severe heatstroke.