痛风清颗粒治疗尿酸性肾病的实验研究

目的]探讨痛风清颗粒对尿酸性肾病大鼠的作用机制。方法]用腺嘌呤加酵母干粉造模,并将大鼠分为正常对照组、模型空白组、小剂量痛风清颗粒治疗组、中剂量痛风清颗粒治疗组、大剂量痛风清颗粒治疗组、利加立仙治疗组。在造模同时,分别给予上述药物灌胃,在实验造模完成后和治疗后分别取血,查尿酸,实验完成后乌拉坦麻醉取右侧肾脏组织,做肾脏病理组织检查,偏光镜观察尿酸盐沉积和肾脏病变情况。结果]与正常组相比,模型空白组和各治疗组血尿酸明显升高(P<0.01);与模型空白组比较治疗组血尿酸明显下降(P<0.05);肾小管扩张、肾小管上皮细胞坏死、管周炎细胞浸润、结缔组织增生、尿酸盐沉积、肾小球萎缩均明显减轻。结论]痛风清颗粒可能通过加速尿酸排泄,从而降血清尿酸,减少尿酸盐结晶在肾脏沉积,达到改善尿酸性肾病肾功能的目的。

Experimental Study of Tongfengqing-Granule on Treatment Urate Nephropathy

Objective] We evaluate the efficacy of the Tongfengqing-qranule on reducing SUA and improving renal function in urate nephropathy SD rats model caused by adenine and yeast.Methods] Forty-six SD rats were randomly divided into six groups: normal group,model group,Benzbromarone group,low dose,middle dose and large dose of Tongfengqing-granule group.Rats were iduced urate nephropathy model by gorged with adenine and yeast.After forty-six days,we put the mouse to death,then draw blood and cut off the kidney f...