| 2型糖尿病动物模型制备方法探讨 |
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| 引用本文： | 王春田,王莉,石岩.2型糖尿病动物模型制备方法探讨[J].实用中医内科杂志,2011,25(4):27-30. |
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| 作者姓名： | 王春田 王莉 石岩 |
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| 作者单位： | 1. 辽宁中医药大学,辽宁沈阳,110032
2. 辽宁中医药大学附属医院,辽宁沈阳,110032 |
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| 摘 要： | 目的]制备2型糖尿病的动物模型并使其发病过程更类似于人类的自然病程。方法]SD成年大鼠高糖高脂饲料喂养4周,诱发出胰岛素抵抗模型。再给予小剂量链脲佐菌素(STZ)45mg/Kg腹腔注射,建立2型糖尿病大鼠模型。结果]相对于正常组大鼠,模型组大鼠体重增加,血糖升高,对胰岛素敏感性下降。结论]人类2型糖尿病大鼠模型制备成功。该模型具有发病过程接近自然,发病率高,死亡率低,模型稳定的优点。
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| 关 键 词： | 2型糖尿病 动物模型 大鼠 |
Discussion on Establishment of Animal Model of Non-Insulin-Dependent Diabetes Mellitus |
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| Authors: | WANG Chun-tian WANG Li SHI Yan |
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| Institution: | 1(1.Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;2.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China) |
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| Abstract: | Objective]Preparation of a disease similar to human type 2 diabetes animal model.Methods]SD adult rats fed high-fat high-sugar 4 weeks,induced insulin resistance,given low-dose streptozotocin(STZ,45mg/kg,intraperitoneal injection),set up in type 2 diabetic rat model.Results]Model group of ratsincreased blood glucose,insulin sensitivity decreased,from the biochemical indices and morphology confirmedthe successful model.Conclusion]The experimental rat model of type 2 diabetes model suecessfully,it hasmoderately high blood sugar,insulin resistance,the success rate is high,are of human type 2 diabetes. |
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| Keywords: | Non-insulin-dependent diabetes mellitus animal model rat |
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