| 鳖甲煎丸对肺纤维化模型大鼠外周血CTGF表达的影响 |
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| 引用本文： | 唐志宇,李天朗,梁江,张泉,熊莉.鳖甲煎丸对肺纤维化模型大鼠外周血CTGF表达的影响[J].实用中医药杂志,2011,27(1):4-5. |
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| 作者姓名： | 唐志宇 李天朗 梁江 张泉 熊莉 |
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| 作者单位： | 1. 四川省德昌县人民医院,四川,德昌,615500
2. 广州中医药大学,广东,广州,510006 |
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| 摘 要： | 目的：探讨鳖甲煎丸对肺纤维化模型大鼠外周血结缔组织生长因子（CTGF）表达的影响。方法：SD大鼠50只随机分为生理盐水对照组、模型对照组、醋酸泼尼松组、鳖甲煎丸中剂量组、鳖甲煎丸高剂量组,采用博莱霉素气管内注入制备肺纤维化模型,造模后各组分别用生理盐水、西药、中药灌胃,第3、14、28天乙醚麻醉后毛细玻管眼眶静脉丛采血,ELISA法检测CTGF表达明显减少,与模型对照组比较有显著性差异（P〈0.05）。结果：模型对照组外周血中CTGF表达明显增加,第14天鳖甲煎丸中、高剂量组外周血CTGF的表达。结论：鳖甲煎丸可抑制肺纤维化模型大鼠外周血CTGF的表达,可能是抗肺纤维化作用的机制之一。
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| 关 键 词： | 大鼠 肺纤维化模型 结缔组织生长因子 鳖甲煎丸 表达影响 |
Effect of Biejiajian Pills on Expression of CTGF in Peripheral Blood of the Pulmonary Fibrosis Model Rats |
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| Tang Zhiyu,Li Tianlang,Liang Jiang et.al.Effect of Biejiajian Pills on Expression of CTGF in Peripheral Blood of the Pulmonary Fibrosis Model Rats[J].Journal of Practical Traditional Chinese Medicine,2011,27(1):4-5. |
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| Authors: | Tang Zhiyu Li Tianlang Liang Jiang etal |
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| Institution: | Tang Zhiyu,Li Tianlang,Liang Jiang et.al |
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| Abstract: | Object: To study the effect of Biejiajian Pills on expression of CTGF(connective tissue growth factor,CTGF) in peripheral blood of the pulmonary fibrosis model rats.Method: 50 SD rats were randomly divided into 5 groups: saline control group,model control group,prednisone acetate group,middle dosage of Biejiajian Pills group and high dosage of Biejiajian Pills group.After the pulmonary fibrosis model was established by intratracheal instillation of bleomycin,each group was given normal saline,western medici... |
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| Keywords: | rat pulmonary fibrosis model CTGF expression effect |
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