| 加味当归芍药散方对糖尿病早期肾损害保护机理探讨 |
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| 引用本文： | 张立赟,赵云芳,王翼华,杨庆平. 加味当归芍药散方对糖尿病早期肾损害保护机理探讨[J]. 实用中医内科杂志, 2011, 25(1): 26-28. DOI: 10.3969/j.issn.1671-7813.2011.01.12 |
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| 作者姓名： | 张立赟 赵云芳 王翼华 杨庆平 |
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| 作者单位： | 1. 河南省南阳市第一人民医院,河南南阳,473000
2. 河南中医学院基础医学院,河南郑州,450000 |
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| 摘 要： | [目的]探讨加味当归芍药散(Jia wei Dang gui Shao yao San,JDSS)对糖尿病早期肾损害的保护机理。[方法]选用动物试验,观察JDSS对实验性糖尿病早期肾损害大鼠血糖(FPG)、血清超氧化物歧化酶(SOD)和丙二醛(MDA)、24h尿微量白蛋白(UALB)、β2-微球蛋白(Uβ2-MG)、内生肌酐清除率(CCr)的影响。[结果]JDSS增高血清SOD含量,降低血清MDA含量及uALB、uβ2-MG(P值均小于0.01),提高CCr(P<0.05)。[结论]JDSS可升高DM大鼠血清SOD的含量,降低血清MDA的含量,减少高血糖引起自由基的生成和动脉硬化的发生,发挥抗氧化应激的作用。
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| 关 键 词： | 糖尿病肾病 加味当归芍药散 SOD MDA |
Study on the Mechanism of Protection About JDSS on the Early Diabetic Nephropathy |
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| ZHANG Li-yun,ZHAO Yun-fang,WANG Yi-hua,YANG Qing-ping. Study on the Mechanism of Protection About JDSS on the Early Diabetic Nephropathy[J]. , 2011, 25(1): 26-28. DOI: 10.3969/j.issn.1671-7813.2011.01.12 |
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| Authors: | ZHANG Li-yun ZHAO Yun-fang WANG Yi-hua YANG Qing-ping |
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| Affiliation: | 1(1.The Endocrine Dept of The First Peopple’Hospital of Nanyang,Henan 473000,Nangyang,China;2.The Preclinical Medicine College of Henan Traditional Chinese Medical University,Zhengzhou 450000,Henan,China) |
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| Abstract: | [Objective]Study on the mechanism of protection about Jia wei Dang gui Shao yao San(JDSS) on the early Diabetic nephropathy(DN).[Method]To observe the effect of the fasting plasma glucose(FPG)、erythrocuprein(SOD) and malonaldehyde(MDA) of serum、24h urine microalbumin(UALB)、β2-microglobulin(β2-MG) and creatinine clearance rate(CCr) of the experimental diabetes rates by animal experiment.[Result]JDSS increase significantly SOD of serum and cut down MDA of serum、uALB、uβ2-MG(P<0.01),improve CCr(P<0.05).[Conclusion]JDSS may heighten SOD of serum of the experimental diabetic rates,and cut down MDA of serum,decrease free radical formation and atherosclerosis development by hyperglycemia.And educe the effect of oxidative stress. |
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| Keywords: | SOD MDA |
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