| 小鼠异位心脏移植模型的建立 |
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| 引用本文： | 吴蔚,杨康,姜恒,李军. 小鼠异位心脏移植模型的建立[J]. 局解手术学杂志, 2003, 12(3): 209-211 |
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| 作者姓名： | 吴蔚 杨康 姜恒 李军 |
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| 作者单位： | [1]第三军医大学西南医院心胸外科，重庆400038 [2]第三军医大学基础部应用解剖与外科手术学教研室 |
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| 摘 要： | 目的 为方便现代移植免疫学研究，建立了小鼠异位心脏移植模型，为今后的器官移植研究打下基础。方法 以昆明鼠为研究对象，参照Ono法并加以改良，将供体升主动脉、肺动脉与受体腹主动脉和下腔静脉行端侧吻合。结果 正式试验50例，8例在72小时以内死亡，其余42例均长期存活，手术成功率为84％。结论 在熟练掌握显微外科技术的基础上，处理好心脏移植的五个关键步骤，小鼠异位心脏移植模型即可顺利建立。
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| 关 键 词： | 小鼠 异位心脏移植 动物模型 移植免疫学 显微外科 血管吻合 |
| 文章编号： | 1672-5042(2003)03-0209-03 |
| 修稿时间： | 2003-08-02 |
Establishing the model of mice heart heterotopic transplantation |
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| WU Wei,YANG Kong,JIANG Heng,et al.. Establishing the model of mice heart heterotopic transplantation[J]. Journal of Regional Anatomy and Operative Surgery, 2003, 12(3): 209-211 |
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| Authors: | WU Wei YANG Kong JIANG Heng et al. |
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| Affiliation: | WU Wei,YANG Kong,JIANG Heng,et al . Department of Cardiothoracic Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038 China |
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| Abstract: | To study the transplantation immunology more conveniently, the model of mice heart heterotopic transplantation wereestablished. Methods Using the Kunming mice for the experiment, the aorta and pulmonary artery of donor' s heart with the abdominal aorta and inferior vena cava of the receptor were anastomosised respectively according to the Ono' s method. Results Formal experiments were performed 50 times. The survival rate was 84% . Conclusion In the basis of mastering the operative technique and handling the five key procedures skillfully, the model of mice heart heterotopic transplantation were established successfully. |
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| Keywords: | mice heart heterotopic transplantation |
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