Reduced E-cadherin expression is associated with lymph node metastases in laryngeal squamous cell carcinoma |
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Authors: | Li Jing-jia Zhang Ge-hua Yang Xin-ming Li Shi-sheng Liu Xian Yang Qin-tai Li Yuan Ye Jin |
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Institution: | Department of Otolaryngology-Head and Neck Surgery, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, PR China. |
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Abstract: | ObjectiveTo investigate the expression of E-cadherin and its relationship with clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC).MethodsSixty-four patients who had previously undergone complete resection of tumor for LSCC were studied retrospectively. The level of E-cadherin expression in tumor tissues and paired nontumor tissues were determined by immunohistochemistry.ResultsThe expression of E-cadherin in tumor tissues was significantly lower than nontumor tissues (P < 0.001). Reduced E-cadherin expression was significantly correlated with lymph node metastases (P < 0.001). Kaplan–Meier survival estimates showed a significant correlation between E-cadherin expression and patient survival rate (log-rank P < 0.05). Multivariate Cox proportional hazards model analysis confirmed that lymph node metastases (P = 0.001) and tumor stage (P = 0.013) were statistically significant, independent predictor of prognosis.ConclusionExpression of E-cadherin is an independent predictor of lymph node metastases in LSCC. However, it does not appear to be a better prognostic predictor than other established markers in LSCC. |
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Keywords: | Larynx Squamous cell carcinoma E-cadherin Metastases Prognosis |
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