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Bordetella pertussis Clones Identified by Multilocus Variable-Number Tandem-Repeat Analysis |
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| Authors: | Jacob Kurniawan Ram P. Maharjan Wai-Fong Chan Peter R. Reeves Vitali Sintchenko Gwendolyn L. Gilbert Frits R. Mooi Ruiting Lan |
| Affiliation: | University of New South Wales, Sydney, New South Wales, Australia (J. Kurniawan, R.P. Maharjan, W.-F. Chan, R. Lan);University of Sydney, Sydney (P.R. Reeves, V. Sintchenko, G.L. Gilbert);Westmead Hospital, Westmead, New South Wales, Australia (V. Sintchenko, G.L. Gilbert);National Institute for Public Health and the Environment, Bilthoven, the Netherlands (F.R. Mooi). |
| Abstract: | Multilocus variable-number tandem-repeat analysis (MLVA) of 316 Bordetella pertussis isolates collected over 40 years from Australia and 3 other continents identified 66 MLVA types (MTs), including 6 predominant MTs. Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia. |
| Keywords: | multilocus variable-number tandem-repeat analysis acellular vaccine antigenic variation Bordetella pertussis global epidemiology bacteria dispatch |