伽玛刀联合洛莫司汀治疗脑多发转移瘤的临床研究

目的伽玛刀联合洛莫司汀治疗脑转移瘤,提高疗效。方法采用病例对照研究的方法,采用本中心2004年1月至2005年9月确诊的脑转移瘤病人178例,病灶数446个,随机分为实验组和对照组,实验组85例病人,220个病灶,在伽玛刀治疗(边缘剂量10~14Gy)后给与洛莫斯汀3.5mg/kg体重顿服化疗,每间隔8周给药一次,共计3次。对照组93例病人,226个病灶单纯采取伽玛刀治疗,每隔3个月复查MRI,统计肿瘤的局控率,病人的生存时间和Karnofsky评分以及并发症情况,样本的生存率,然后进行统计学分析。结果实验组的肿瘤局控率,治疗后KPS评分及生存时间、生存率均高于对照组,而并发症的发生率两组间无差异。结论伽玛刀联合洛莫司汀治疗脑转移瘤是一种有效的措施,效果较单纯伽玛刀佳。

The clinical case-contral report of gamma knife radiosurgery ally lumostine treat cerebral meteastases

Objective To investigate the clinical effects of gamma knife radiosurgery and lumositine on cerebral meteastases.Methods The cases are divided into experiment and contral group in random from January first 2004 to September thirty 2005 in Taiyuan Gamma Knife Center.The experimental group includes 80 patients with 211 brain metastases are chemotherapied by lumostine after gamma knife radiosurgery.Lumostine is given to the patients every 8 weeks.Three times chemotherapys are given to every course.The contral group of 87 patients with 205 malignant brain tumors are only treated by gamma knife radoisurgery.Then analyse the difference of the two group in software SPSS12.0.Results The case group are higher than the contral in the reduce-ratio of tumors,Karnofsky rates and surrival-rate.But there is not diffence in complementary between the two groups.Conclusion Lumostine chemotherapy is an effective treatment after gamma knife radiosurgery for the cerebral meteastases and more effectual than the only radiosurgery.