| 卡介苗免疫预防小鼠白色念珠菌感染的实验研究 |
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| 引用本文： | 李丽波,王玉祥. 卡介苗免疫预防小鼠白色念珠菌感染的实验研究[J]. 齐齐哈尔医学院学报, 2009, 30(14): 1665-1666 |
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| 作者姓名： | 李丽波 王玉祥 |
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| 作者单位： | 齐齐哈尔医学院,161006 |
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| 摘 要： | 目的探讨卡介苗（BCG）预先免疫对小鼠白色念珠菌感染的影响。方法采用BCG或灭菌生理盐水皮内注射预先免疫2周,然后由尾静脉注射白色念珠菌进行攻击,观察小鼠死亡率及计算存活小鼠肾组织带菌量。结果BCG免疫组存活时间长于生理盐水免疫组（P〈0.01）;存活小鼠肾组织菌落计数：BCG免疫组远少于省里盐水免疫组（P〈0.01）。结论BCG对小鼠白色念珠菌感染具有很好的保护作用。
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| 关 键 词： | 卡介苗 白色念珠菌 菌落计数 |
Study on pre-immunization with Bacillus Calmette-Guerin (BCG) on Candida albicans infection in mice |
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| Affiliation: | LI Li -- bo, et al. (Qiqihar Medical University, Qiqihar, Heilongjiang 161006 China) |
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| Abstract: | Objective To investigate the effect of preimmunization with Bacillus Calmette-Guerin (BCG) on Candida albicans infection in mice. Methods BCG or 0.9% sterile saline was injected intracutaneously to ICR mice for preimmunization for two weeks before inoculation of Candida albicans by vena caudalis injection, then mortality rate of mice was observed and Candida albicans in mice kidney was examined. Results Survival time in BCG preimmunization group was longer than that in 0.9% sterile saline group (P<0.01); colony count of Candida albicans in mice kidney in BCG preimmunization group was less than that in saline group (P < 0.01). Conclusions BCG pre-immunization has protective effect from Candida albicans infection in mice. |
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| Keywords: | Bacillus Calmette-Guerin (BCG) Candida albicans Colony count |
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