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Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure |
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| Authors: | C. W. Howden C. D. Payton P. A. Meredith D. M. A. Hughes A. I. Macdougall J. L. Reid J. A. H. Forrest |
| Affiliation: | (1) University Department of Materia Medica, Stobhill General Hospital, Glasgow, Scotland, U.K.;(2) Renal Unit, Stobhill General Hospital, Glasgow, Scotland, U.K.;(3) Gastroenterology Unit, Stobhill General Hospital, Glasgow, Scotland, U.K. |
| Abstract: | Summary The inhibitory effect of omeprazole on gastric acid secretion was tested in a group of patients on haemodialysis for chronic renal failure. Single 30 mg doses almost totally inhibited basal acid output on both dialysis and non-dialysis days. Plateau acid output was reduced by a mean of 77% and 90% on non-dialysis and dialysis days respectively. The absorption and pharmacokinetic profile of omeprazole were not affected by dialysis. Omeprazole was not recoverable from dialysis fluid. It is concluded that omeprazole is a potent inhibitor of gastric acid secretion in patients with chronic renal failure, and its effect is not influenced by haemodialysis. |
| Keywords: | omeprazole renal failure gastric secretion pharmacokinetics haemodialysis |
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