高压氧对脑梗死后血清一氧化氮和一氧化氮合酶含量的影响

目的 研究高压氧对脑梗死后血清一氧化氮、一氧化氮合酶含量的影响。方法 将脑梗死患者分为高压氧治疗组和非高压氧治疗组,观察不同病期血清一氧化氮、一氧化氮合酶含量的变化,并与正常对照组进行比较。结果 高压氧治疗组一氧化氮含量较非高压氧治疗组上升快,在治疗后15天恢复正常,但在一疗程高压氧治疗结束后,却又有所下降;一氧化氮合酶含量在治疗后均有上升,未能恢复到正常水平,两组之间无差异。结论 高压氧通过提高NO的含量,减轻缺血区脑组织的损伤,改善脑血循环;高压氧对NOS有一定影响,但作用不大;应适当延长高压氧疗程,尽可能缓解因NOS含量下降所造成的NO释放量不足。

A study of the effect of hyperbaric oxygenation on nitric oxide and nitric oxide synthase in serum after cerebral infarction

To study the effect of hyperbaric oxygenation(HBO) on nitric oxide (NO) and nitric oxide synthase(NOS) after cerebral infarction. Methods: Patients with cerebral infartion were divided into group A (tleated with HBO treatment) and group B(without HBO). Changes of NO and NOS in serum were observed at various period, and compared with nomal control. Results:The level of NO in group A were more elevated than that in group B. It recovered to normal level 15days after treatment, but deceased again following the end of HBO;NOS were elevated after treatment,but without significant difference between the groups, It could not recover to normal yet. Conclusion:HBO can reduce brain damages of cerebral ischemia and improve cerebral blood flow by increasing level of NO. HBO behaveslittle effect on NOS;It is supposed that prolonging the course of HBO, might al-leviats as far as possible the lack of NO.