Nonalcoholic steatohepatitis and hepatocellular carcinoma: Beyond the boundaries of the liver |
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Authors: | Tarana Gupta |
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Institution: | Tarana Gupta, Department of Medicine, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak 124001, Haryana, India |
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Abstract: | The burden of non-alcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) is drawing attention due to the emerging epidemic of obesity and metabolic syndrome and is expected to increase in the near future. Antidiabetic medications, air pollutants, and newer genetic mutations are latest concerns as risk factors for HCC development in patients with NASH. Although molecular signatures are very accurate, they are not cost-effective and cannot be applied in larger population due to logistic issues. We need multicentric longitudinal studies including diverse geographical areas to evaluate the complex interplay of different risk factors and genetics in these patients. |
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Keywords: | Non-alcoholic steatohepatitis Hepatocellular carcinoma Cirrhosis Genetic factors Lifestyle factors Surveillance |
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