三种结核潜伏感染试验在HIV感染人群中的应用评价

目的 评价AIMTB和T-SPOT检测方法在人类免疫缺陷病毒（human immunodeficiency virus,HIV）感染人群中结核潜伏感染的诊断效能。方法 收集2022年9～10月在广西壮族自治区疾病预防控制中心门诊就诊的HIV感染者的血样标本，使用雷德AIMTB、迪奥T-SPOT和凯杰QFT三种方法进行检测，以QFT作为参照对检测结果进行诊断效能评价。结果 AIMTB方法检出阳性率为54.6%，敏感度、特异性分别为84.72%、76.19%;T-SPOT方法检出阳性率为57.6%，敏感度和特异性分别为88.89%、73.02%。AIMTB方法和T-SPOT方法与QFT方法比较结果具有一致性（P<0.001）。结论AIMTB方法和T-SPOT方法均具有较高的阳性检出率，与QFT方法的一致性较好，可加大样本量进一步验证及推广。

Evaluation of three latent tuberculosis infection tests in HIV-infected population

Objective To evaluate the effectiveness of AIMTB and T-SPOT tests in the diagnosis of latent tuberculosis infection in human immunodeficiency virus (HIV) infected population. Methods Collect blood samples from HIV-infected patients in the outpatient department of Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention from September to October 2022. The blood samples were tested by three methods: AIMTB, T-SPOT and QFT test. The test results were evaluated by diagnostic tests with QFT as a reference. Results The positive rate of AIMTB was 54.6%, the sensitivity and specificity were 84.72% and 76.19%, respectively. The positive rate of T-SPOT was 57.6%, the sensitivity and specificity were 88.89% and 73.02%, respectively. AIMTB and T-SPOT were consistent with QFT test (P<0.001). Conclusion AIMTB and T-SPOT have high positive detection rates, and they are consistent with QFT test, which can be further verified and popularized by increasing the samples.