三种结核潜伏感染试验在HIV感染人群中的应用评价 |
| |
引用本文: | 周崇兴,梁大斌,黄彦,崔哲哲,覃慧芳,黄莉雯,区进,叶婧. 三种结核潜伏感染试验在HIV感染人群中的应用评价[J]. 中国现代医生, 2023, 60(16): 23-26 |
| |
作者姓名: | 周崇兴 梁大斌 黄彦 崔哲哲 覃慧芳 黄莉雯 区进 叶婧 |
| |
作者单位: | 广西壮族自治区疾病预防控制中心 广西重大传染病防控与生物安全应急响应重点实验室,广西南宁 530028 |
| |
基金项目: | 广西科技计划项目(桂科AB18221010);广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20220357,Z-A20220360) |
| |
摘 要: | 目的 评价AIMTB和T-SPOT检测方法在人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染人群中结核潜伏感染的诊断效能。方法 收集2022年9~10月在广西壮族自治区疾病预防控制中心门诊就诊的HIV感染者的血样标本,使用雷德AIMTB、迪奥T-SPOT和凯杰QFT三种方法进行检测,以QFT作为参照对检测结果进行诊断效能评价。结果 AIMTB方法检出阳性率为54.6%,敏感度、特异性分别为84.72%、76.19%;T-SPOT方法检出阳性率为57.6%,敏感度和特异性分别为88.89%、73.02%。AIMTB方法和T-SPOT方法与QFT方法比较结果具有一致性(P<0.001)。结论AIMTB方法和T-SPOT方法均具有较高的阳性检出率,与QFT方法的一致性较好,可加大样本量进一步验证及推广。
|
关 键 词: | 结核 γ干扰素释放试验 结核潜伏感染 |
Evaluation of three latent tuberculosis infection tests in HIV-infected population |
| |
Abstract: | Objective To evaluate the effectiveness of AIMTB and T-SPOT tests in the diagnosis of latent tuberculosis infection in human immunodeficiency virus (HIV) infected population. Methods Collect blood samples from HIV-infected patients in the outpatient department of Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention from September to October 2022. The blood samples were tested by three methods: AIMTB, T-SPOT and QFT test. The test results were evaluated by diagnostic tests with QFT as a reference. Results The positive rate of AIMTB was 54.6%, the sensitivity and specificity were 84.72% and 76.19%, respectively. The positive rate of T-SPOT was 57.6%, the sensitivity and specificity were 88.89% and 73.02%, respectively. AIMTB and T-SPOT were consistent with QFT test (P<0.001). Conclusion AIMTB and T-SPOT have high positive detection rates, and they are consistent with QFT test, which can be further verified and popularized by increasing the samples. |
| |
Keywords: | |
|
| 点击此处可从《中国现代医生》浏览原始摘要信息 |
|
点击此处可从《中国现代医生》下载全文 |
|