Current guidelines in the surgical management of hereditary colorectal cancers |
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Authors: | Shantata Kudchadkar Safia Ahmed Tanmoy Mukherjee Jayesh Sagar |
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Affiliation: | Shantata Kudchadkar, Safia Ahmed, Tanmoy Mukherjee, Jayesh Sagar, Department of Colorectal Surgery, Luton & Dunstable University Hospital NHS Foundation Trust, Luton LU4 0DZ, United Kingdom |
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Abstract: | Incidence of colorectal cancer (CRC) is on rise. While approximately 70% of all CRC cases are sporadic in nature, 20%-25% have familial aggregation and only < 5% is hereditary in origin. Identification of individuals with hereditary predilection for CRC is critical, as it has an impact on their overall surgical management including surgical timing, approach & technique and determines the role of prophylactic surgery and outcome. This review highlights the concept of hereditary CRC, provides insight into its molecular basis, possibility of its application into clinical practice and emphasizes the current treatment strategies with surgical management, based on the available international guidelines. |
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Keywords: | Colorectal cancer Lynch syndrome Familial adenomatosis polyposis Immunohistochemistry Metachronous colon cancer |
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| 点击此处可从《World journal of gastrointestinal oncology》浏览原始摘要信息 |
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