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Diabetes and cognitive decline: Challenges and future direction |
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| Authors: | Norhamidar Ab-Hamid Norsuhana Omar Che Aishah Nazariah Ismail Idris Long |
| Affiliation: | Norhamidar Ab-Hamid, Idris Long, Biomedicine program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, MalaysiaNorsuhana Omar, Che Aishah Nazariah Ismail, Department of Physiology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia |
| Abstract: | There is growing evidence that diabetes can induce cognitive decline and dementia. It is a slow, progressive cognitive decline that can occur in any age group, but is seen more frequently in older individuals. Symptoms related to cognitive decline are worsened by chronic metabolic syndrome. Animal models are frequently utilized to elucidate the mechanisms of cognitive decline in diabetes and to assess potential drugs for therapy and prevention. This review addresses the common factors and pathophysiology involved in diabetes-related cognitive decline and outlines the various animal models used to study this condition. |
| Keywords: | Diabetes mellitus Insulin signaling Macrovascular disease Microvascular disease Animal models Cognitive decline Pathophysiology |
| 点击此处可从《World journal of diabetes》浏览原始摘要信息 | |