Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment |
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| Affiliation: | 1. Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany;2. German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany;3. Graduate School of Neural & Behavioural Sciences, Tuebingen, Germany;4. Graduate School of Neural Information Processing, Tuebingen, Germany;5. Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, Tuebingen, Germany;6. University Hospital Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany;7. LEAD Graduate School, University of Tuebingen, Germany;8. Center of Integrative Neuroscience (CIN), Cluster of Excellence, University of Tuebingen, Germany;1. Environmental Neuroscience Lab, Department of Psychology, The University of Chicago, 5848 S University Avenue, Chicago, IL 60637, United States;2. Mansueto Institute for Urban Innovation, The University of Chicago, United States;3. Department of Electrical and Computer Engineering, The University of Pittsburgh, United States;4. Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, United States |
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| Abstract: | BackgroundTo determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI).MethodsThirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO2), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF.ResultsReductions in nTCBF by 9%, CMRO2 by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO2 in normal controls, but not in aMCI.ConclusionsGlobal brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology. |
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| Keywords: | Mild cognitive impairment Cerebral blood flow Cerebral metabolic rate of oxygen Ultrasonography Near-infrared spectroscopy MRI |
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