Baseline Serum 25-Hydroxyvitamin D Levels in Men Undergoing Radical Prostatectomy: Is There An Association With Adverse Pathologic Features? |
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| Institution: | 1. Department of Urology, Medical University of Innsbruck, Innsbruck, Austria;2. Division of General Pathology, Department of Pathology, Medical University of Innsbruck, Innsbruck, Austria;4. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA;5. Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY;6. Department of Epidemiology, University of Washington, Seattle, WA;7. Department of Biostatistics, University of Washington, Seattle, WA;1. Harvard Radiation Oncology Program, Boston, MA;2. Department of Statistics, University of Connecticut, Storrs, CT;3. Department of Pathology, Brigham and Women''s Hospital, Boston, MA;4. Division of Urology, Brigham and Women''s Hospital, Boston, MA;5. Harvard Medical School, Boston, MA;6. Department of Radiation Oncology, Brigham and Women''s Hospital/Dana-Farber Cancer Institute, Boston, MA;1. Institute for Drug Development, Cancer Therapy and Research Center (CTRC), University of Texas Health Science Center, San Antonio, TX;2. Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX;1. Unidad de Cuidados Intensivos Pediátricos, Hospital Guillermo Grant Benavente, Concepción, Chile;2. Laboratorio de Biología del Ejercicio, Escuela de Kinesiología, Facultad de Ciencias de la Salud, Universidad San Sebastián, Concepción, Chile;3. Servicio de Pediatría, Hospital Guillermo Grant, Concepción, Chile;1. The Center for Structural and Functional Neurosciences, The University of Montana, Missoula, MT 59812, USA;2. Hospital Central Militar, Mexico City 11649, Mexico;3. Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6;4. Escuela de Ciencias de la Salud, Universidad del Valle de México, Saltillo, Coahuila 25204, Mexico;5. Clinical and Environmental Laboratory Micro Trace Minerals (MTM), 91217 Hersbruck, Germany;6. Mathematics Department, Boise State University, Boise, Idaho, USA;7. Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, 04510, Mexico;8. College of Sciences, University of Texas at San Antonio, San Antonio, TX, USA |
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| Abstract: | Introduction/BackgroundThe purpose of this study was to evaluate the prevalence of vitamin D (VitD) deficiency in men undergoing radical prostatectomy and determine whether an association exists between preoperative VitD levels and adverse pathologic features.Patients and MethodsPatients scheduled to undergo radical prostatectomy for clinically localized disease from January to August 2012 were prospectively followed and those with available preoperative serum 25-hydroxyvitamin D levels were included. Men with a known diagnosis of VitD deficiency or taking VitD supplementation were excluded. Cox regression analysis was performed to determine whether preoperative VitD level is predictive of adverse pathologic outcomes.ResultsOne hundred consecutive men were included. Mean age was 62 (range, 42-79) years and mean VitD level was 26 (range, 6-57) ng/mL. Overall, 65 men (65%) had suboptimal levels of VitD (< 30 ng/mL), and 32 (32%) had deficiency (< 20 ng/mL). There was no significant correlation between VitD and age (P = .5). In logistic regression analysis, VitD level was not predictive of pathologic Gleason (P = .11), pathologic stage (P = .7), or positive margin status (P = .8).ConclusionThe association between VitD and prostate cancer has been controversial and data suggesting an increased risk of aggressive cancer in men with low levels of VitD have been inconsistent. We found that baseline preoperative VitD level was not associated with any adverse pathologic features. However, VitD deficiency is a common finding in this population, although unrelated to patient age. These results represent the first time the correlation between VitD and prostate cancer has been evaluated in a cohort of men undergoing radical prostatectomy. |
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| Keywords: | Cancer Nutritional status Outcome assessment Prostatic neoplasm Vitamin D |
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