| 细菌生物膜在肿瘤生物学进程及治疗应用中的研究进展 |
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| 引用本文： | 黄永平,李梦洁,孙玉芳,项涛. 细菌生物膜在肿瘤生物学进程及治疗应用中的研究进展[J]. 实用肿瘤学杂志, 2022, 36(5): 440-444. DOI: 10.11904/j.issn.1002-3070.2022.05.009 |
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| 作者姓名： | 黄永平 李梦洁 孙玉芳 项涛 |
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| 作者单位： | 1.西南交通大学附属医院/成都市第三人民医院急诊科(成都 610031);2.昆明医科大学第三附属医院/云南省肿瘤医院胸外一科;3.四川省骨科医院足踝一科 |
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| 基金项目： | 云南省教育厅科学研究基金(编号:2019Y0362) |
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| 摘 要： | 细菌生物膜是细菌及其胞外聚合物形成的微生物群体，具有增强抗生素抵抗及抗宿主免疫等能力。肿瘤微环境中的细菌生物膜具有诱导炎症-癌症转化、促进癌细胞增殖转移和增强肿瘤耐药性等作用，影响着肿瘤的生物学进程。此外，细菌生物膜还被证实可协同抗癌药物抑制肿瘤细胞增殖、促进抗癌药物靶向定植及增强宿主免疫功能。本文就细菌生物膜在影响恶性肿瘤发生发展及抗肿瘤治疗中的研究进行综述。
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| 关 键 词： | 细菌生物膜 肿瘤 感染 |
| 收稿时间： | 2022-07-14 |
Research progress of bacterial biofilms in tumor biological processes and therapeutic applications |
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| HUANG Yongping,LI Mengjie,SUN Yufang,XIANG Tao. Research progress of bacterial biofilms in tumor biological processes and therapeutic applications[J]. Journal of Practical Oncology, 2022, 36(5): 440-444. DOI: 10.11904/j.issn.1002-3070.2022.05.009 |
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| Authors: | HUANG Yongping LI Mengjie SUN Yufang XIANG Tao |
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| Affiliation: | 1. Department of Emergency,The Third People's Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University,Chengdu 610031,China;2. Department of Thoracic Surgery One,The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital;3. Department of Foot Ankle One,Sichuan Orthopaedic Hospital |
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| Abstract: | Bacterial biofilm is a microbial population formed by bacteria and extracellular polymers,which has the ability to enhance antibiotic resistance and anti-host immunity.Bacterial biofilms in the tumor microenvironment can induce inflammation-cancer transformation,promote cancer cell proliferation and metastasis,and enhance tumor drug-resistance,which affect the biological process of tumors.In addition,bacterial biofilms have also been shown to synergize with anticancer drugs to inhibit cancer cell proliferation,promote targeted colonization of anticancer drugs,and enhance host immune function.This paper reviews the research on bacterial biofilms in influencing the occurrence,development and anti-tumor treatment of malignant tumors. |
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| Keywords: | Bacterial biofilms Tumor Infection |
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