Hot topics in pancreatic cancer management |
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Authors: | Damiano Caputo |
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Affiliation: | Damiano Caputo, Department of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome 00128, ItalyDamiano Caputo, General Surgery Research Unit, University Campus Bio-Medico di Roma, Rome 00128, Italy |
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Abstract: | Pancreatic ductal adenocarcinoma (PDAC) is a sneaky and lethal disease burdened by poor prognosis. PDAC is often detected too late to be successfully cured, and it has been estimated that it will be a leading cause of cancer-related deaths in the near future. During the last decade, multimodal treatments involving surgery, chemotherapy and radiotherapy have contributed to improving the prognosis of this disease; however, long-term results are still not satisfactory. Postoperative morbidity and mortality rates remain high, and systemic treatments are burdened by toxicity in both neoadjuvant and adjuvant settings. Advancements in technologies, targeted therapies, immunotherapy and PDAC microenvironment modulation strategies may represent useful potential weapons in the future. Nevertheless, in the fight against this dreadful disease, there is an urgent need for new, cheap and user-friendly tools for early detection. In this field, promising results have been found in nanotechnologies and “omics” analyses that search for new biomarkers to be used in primary and secondary prevention. However, there are many issues that need to be solved before considering these tools in daily clinical practice. This editorial reported the state of the art of pancreatic cancer management. |
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Keywords: | Pancreatic cancer Pancreatic ductal adenocarcinoma Nanotechnology Neoadjuvant therapy Adjuvant therapy Omics |
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| 点击此处可从《World journal of gastrointestinal surgery》浏览原始摘要信息 |
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