40例急性胰腺炎患者血清淀粉样蛋白A及炎症因子的变化

目的 :观察血清SAA、CRP、IL - 6、IL - 8及SIL - 2R在急性胰腺炎病程中的变化 ,探讨SAA在急性胰腺炎发生发展中的辅助诊断及疾病严重度评价的实用价值。方法 :SAA、CRP定量检测 :采用乳胶增强速率散射比浊法。IL - 6、IL - 8、SIL - 2R水平采用ABC -ELISA法检测。结果 :急性重症胰腺炎患者五项指标显著高于急性轻症胰腺炎及正常对照组 (p <0 0 1 )。同时血清SAA水平与CRP、IL - 6、IL - 8水平呈显著相关 (p <0 0 1 )。急性轻症胰腺炎组SAA、CRP、IL - 6水平高于正常对照组 (p <0 0 5 )。 结论 :联合检测血清SAA、CRP、IL - 6、IL - 8水平对判断急性重症胰腺炎的严重程度及提示急性胰腺炎坏死性形成具有重要参考价值。在急性胰腺炎的病程中SAA的检测价值优于CRP。

Changes of Serum Amyloid A,C-Reactive Protein and Interleukin Pattern Contents in 40 Patients with Acute Pancreatitis

Objective To explore the relationship between the serum level changes of amyloid A protein(SAA) , C vreactive protein(CRP), interleukin-6(IL-6), interleukin-8(IL-8), solublized-interleukin-2-receptor (SIL-2R) and the process of acute pancreatitis with special emphasis on the practical value of SAA as an early prediction of severty. Methods Serum SAA and CRP were detected with latex-enhanced nephelometric immunoassay and IL-6, IL-8, SIL-2R were measured with enzyme linkded immunosorbentassay(ELISA). Results The concentrations of the five parametors in the patients with severe pancreatitis were significantly higher than those in patients with mild acute pancreatitis patients and healthy controls( p <0 01). The SAA conccntration were positively correlated to the levels of CRP, IL-6, IL-8 ( p <0 01). The serum levels of SAA, CRP and IL-6 in patients with mild acute pancreatitis were also significantly higher than those in the healthy controls ( p <0 05). Conclusion Combined measurement of these five parametors may be of great importance in the evaluation of the severity and prognosis for acute pancreatitis. SAA is a better predictor of serverity than CRP.