| 新型脂质体在经皮给药系统中的应用 |
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| 引用本文： | 毛雨婷,纪宏宇,郑东友,穆滨,唐景玲,高亚男,吴琳华. 新型脂质体在经皮给药系统中的应用[J]. 中国药师, 2015, 0(12): 2141-2144 |
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| 作者姓名： | 毛雨婷 纪宏宇 郑东友 穆滨 唐景玲 高亚男 吴琳华 |
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| 作者单位： | 哈尔滨医科大学附属第二医院药学部 哈尔滨 150086；哈尔滨医科大学药学院；黑龙江省高校重点实验室；;哈尔滨医科大学附属第二医院药学部；哈尔滨医科大学药学院；黑龙江省高校重点实验室；;哈尔滨医科大学附属第二医院药学部;哈尔滨市康隆药业有限公司;哈尔滨医科大学药学院；黑龙江省高校重点实验室；;哈尔滨医科大学药学院；黑龙江省高校重点实验室；;哈尔滨医科大学附属第二医院药学部；哈尔滨医科大学药学院；黑龙江省高校重点实验室； |
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| 基金项目： | 黑龙江省应用技术研究与开发计划项目(编号:GC13C114) |
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| 摘 要： | 摘 要 药物经皮传递系统的角质层屏障等问题日益受到关注，而新型脂质体作为药物传递载体，可以有效解决这一问题。新型脂质体能明显提高药物经皮渗透，从而增强疗效，具有广阔的应用价值和开发前景。本文结合国内外研究现状，对在经皮给药系统中作为载体应用的新型脂质体的分类、促渗机制及其应用进展做一综述。
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| 关 键 词： | 新型脂质体；醇质体；传递体；类脂囊泡；前体脂质体；经皮给药；应用 |
| 收稿时间： | 2015-07-30 |
| 修稿时间： | 2015-08-23 |
Application of Novel Liposomes in Transdermal Drug Delivery System |
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| Affiliation: | Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; College of Pharmacy, Harbin Medical University; Key Laboratory of Drug Research, College of Heilongjiang Province;;Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University; College of Pharmacy, Harbin Medical University; Key Laboratory of Drug Research, College of Heilongjiang Province;;Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University;Harbin Kanglong Pharmaceutical Co. Ltd;College of Pharmacy, Harbin Medical University; Key Laboratory of Drug Research, College of Heilongjiang Province;;College of Pharmacy, Harbin Medical University; Key Laboratory of Drug Research, College of Heilongjiang Province;;Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University; College of Pharmacy, Harbin Medical University;Key Laboratory of Drug Research, College of Heilongjiang Province; |
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| Abstract: | ABSTRACT The stratum corneum barrier and the other issues in transdermal drug delivery system have attracted more and more attention, and the novel liposomes as the drug delivery vehicles effectively solve the problems. The novel liposomes can significantly improve transdermal drug penetration, therefore, can enhance efficacy and shows high application value and development prospects. In the paper, combined with some domestic and foreign current researches, the classification, penetration mechanisms and application of the novel liposomes were reviewed. |
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| Keywords: | Novel liposomes Ethosomes Transfersomes Niosomes Proliposomes Transdermal delivery Application |
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