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Multi-walled carbon nanotubes: Lack of mutagenic activity in the bacterial reverse mutation assay |
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| Authors: | Antonella Di Sotto Massimo Chiaretti Giovanna Angela Carru Stefano Bellucci Gabriela Mazzanti |
| Institution: | 1. Department of Physiology and Pharmacology “Vittorio Erspamer”, “Sapienza” University, P.le Aldo Moro 5, 00185 Rome, Italy;2. General Surgery Department “Paride Stefanini”, “Sapienza” University, Viale del Policlinico 155, 00185 Rome, Italy;3. INFN Frascati National Laboratories, Via Enrico Fermi 40, 00044 Frascati, Rome, Italy |
| Abstract: | The mutagenic effect of multi-walled carbon nanotubes (MWCNTs) characterised by small surface/volume ratio, high diameter and less than 0.1% of metal contaminants was evaluated by the bacterial reverse mutation assay (Ames test) on Salmonella typhimurium TA 98 and TA 100 strains, and on Escherichia coli WP2uvrA strain, in presence and in absence of the metabolic activation system S9. A preliminary cytotoxicity assay was carried out to ensure that cytotoxicity did not interfere with response. |
| Keywords: | Multi-walled carbon nanotubes (MWCNTs) Nanoparticles Ames test Mutagenicity Bacterial reverse mutation assay |
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