Decreased aortic contractile reaction to 5-hydroxytryptamine in rats with long-term hypertension induced by lead (Pb) exposure |
| |
| Authors: | Le-Feng Zhang Shuang-Qing Peng Sheng Wang |
| |
| Affiliation: | 1. Evaluation and Research Center for Toxicology, Institute of Disease Control and Prevention, Academy Of Military Medical Sciences, 20 Dong Da Jie Street, FengTai District, Beijing 100071, PR China;2. Department of Occupational and Environmental Health, School of Public Health, Peking University Health Science Center, Beijing 100083, PR China;3. Department of Occupational and Environmental Health, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, PR China |
| |
| Abstract: | Male Wistar rats were exposed to 100 ppm Pb2+ in drinking water for 10 months. Tail blood pressure, serum 5-hydroxytryptamine (5-HT), the expression of 5-HT2B receptor in the aorta, the aortic response to 5-HT, and the pathologic changes of aorta were examined. The systolic blood pressure of Pb2+ exposed group was significantly increased after 2 months of Pb2+ exposure. After 10 months of Pb2+ exposure, aortic contractile response to 5-HT was significantly decreased. There was no significant difference in the levels of serum 5-HT and the expression of 5-HT2B receptor between these two groups. The aortic media and the media-lumen ratio of Pb2+ exposed group were significantly increased. These data suggest that long-term Pb2+ exposure can increase blood pressure, and can alter the function and structure of aortic of rats. The decreased aortic response to 5-HT has little relation to the expression of 5-HT2B receptor and the serum level of 5-HT, maybe is a result of the aortic structural alteration. |
| |
| Keywords: | Lead (Pb2+) toxicity Hypertension Aorta Vascular reactivity 5-HT Structure |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
