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Bivariate genome-wide linkage analysis for traits BMD and AAM: Effect of menopause on linkage signals |
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| Authors: | Zhi-Xin Zhang Shu-Feng Lei Fei-Yan Deng Feng Zhang Yong-Jun Liu Robert R. Recker Christopher J. Papasian Hong-Wen Deng |
| Affiliation: | 1. Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an Shaanxi 710049, PR China;2. School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA;3. Department of Biomedical Sciences and Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, NE 68131, USA |
| Abstract: | Osteoporosis is an age-related systemic skeletal disease, characterized by low bone mineral density (BMD). Low BMD is closely associated with late age at menarche (AAM). Our previous bivariate genome-wide linkage analyses (GWLAs) between BMD and AAM identified two shared genomic regions in 2584 Caucasian females including both pre- and post-menopausal females. However, menopause often causes dramatic bone loss in post-menopausal females; this may introduce some confounding effects on the bivariate GWLA for BMD and AAM. |
| Keywords: | Genome-wide linkage analysis Bone mineral density Age at Menarche Menopause |
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