The effect of short-term aerobic training on coagulation and fibrinolytic factors in sedentary healthy postmenopausal women |
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Authors: | Tahereh Jahangard Giti Torkaman Babak Ghoosheh Mehdi Hedayati Azadeh Dibaj |
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Institution: | 1. Physical Therapy Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, PO Box 14115-331, Islamic Republic of Iran;2. Department of Cardiac Rehabilitation, Rofayde Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Islamic Republic of Iran;3. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran;4. Health Center of Tarbiat Modares University, Tehran, Islamic Republic of Iran |
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Abstract: | ObjectiveThe purpose of this study was to assess the effect of short-term aerobic training on the fibrinolytic and coagulative factors in postmenopausal women.Study designTwenty volunteer sedentary healthy postmenopausal women (48–53 years), who entered the menopause naturally, were divided randomly into two groups: training (n = 10) and control (n = 10).Methods and main outcome measuresTraining consisted of 10 sessions of submaximal aerobic cycling, 35 min for each session (5 min warm-up, 25 min aerobic training with 70% HRmax, 5 min active and 15 min passive recovery), 3 times a week. Coagulation and fibrinolytic factors were assessed both before and after aerobic program in both groups.ResultsFibrinogen, von Willbrand factor (vWF-Ag) antigen, plasminogen activator inhibitor-1 activity (PAI-1:Ac) and antigen (PAI-1:Ag) showed significant reduction after 10 sessions in the training group (P < 0.05). Also after training, prothrombin time (PT), partial thromboplastin time (PTT), tissue plasminogen activator activity (tPA:Ac) and antigen (tPA:Ag) increased (P < 0.05).ConclusionIt was concluded that fibrinolytic activity on postmenopausal women could be improved by a 3-week regular submaximal training program. These changes on the hemostatic factors suggest that short-term aerobic training may prevent the decline in fibrinolytic function observed in sedentary postmenopausal women. |
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Keywords: | Short-term aerobic training Coagulation Fibrinolysis Postmenopausal |
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