瑞舒伐他汀/辛伐他汀治疗慢性心力衰竭的疗效比较

目的：比较瑞舒伐他汀和辛伐他汀对慢性心力衰竭（ CHF）的疗效。方法选取CHF患者108例，随机分为两组，在常规治疗的基础上，分别加用辛伐他汀（20 mg/d）和瑞舒伐他汀（20 mg/d）治疗，疗程为6个月。在治疗前后，检测患者低密度脂蛋白胆固醇（ LDL-C）、高密度脂蛋白胆固醇（ HDL-C）、高敏C反应蛋白（ hs-CRP）、B型尿钠肽（ BNP）、左室射血分数（ LVEF）、左室舒张末内径（ LVEDD），并评估纽约心脏病学会（ NYHA）心功能分级，记录6 min步行距离。结果瑞舒伐他汀组和辛伐他汀组总有效率分别为90.74％、75.93％，有统计学差异（ P﹤0.05）。治疗后，两组LVEF、LVEDD、LDL-C、hs-CRP、BNP和6 min步行距离均较治疗前有所改善（P﹤0.05），且瑞舒伐他汀组较辛伐他汀组改善程度更明显（P﹤0.05）。结论瑞舒伐他汀联合常规治疗对CHF疗效优于辛伐他汀联合常规治疗，值得推广。

Comparison of curative effects between rosuvastatin and simvastatin on chronic heart failure

Objective To compare the curative effects of rosuvastatin and simvastatin on chronic heart failure（ CHF ）. Methods 108 patients of CHF were randomly divided into 2 groups：rosuvastatin group and simvastatin group. The routine treatment was applied to both groups,while simvastatin,20 mg/d,was added to patients in simvastatin group and rosuvastatin,20 mg/d,to patients in rosuvastatin group;the total course lasted for 6 months. Before and after treatment,detections of LDL-C,HDL-C,hs-CRP,BNP,LVEF and LVEDD were performed as well as the evaluation of cardiac function according to New York Heart Association（ NYHA ） classification and the distance of 6-minute walk test（6MWT）. Results The total effective rate was 90. 74% in rosuvastatin group and 75.93% in simvastatin group,the difference was of statistical significance（P ﹤0. 05）;improvement in LVEF,LVEDD,LDL-C,hs-CRP,BNP and 6MWT was found in both groups after treatment（P﹤0. 05）and the improvement in rosuvastatin group was greater than that in simvastatin group（P﹤0. 05）. Conclusions The effect of rosuvastatin combined with routine treatment is much superior to that of simvastatin on CHF,and a wider clinical application should be promoted.