| 白细胞介素6基因多态性与冠心病易感性的Meta分析 |
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| 引用本文： | 高敏,邹延峰,冯晓亮,潘发明,苏虹,范引光,王静,张承业,叶冬青. 白细胞介素6基因多态性与冠心病易感性的Meta分析[J]. 中国临床保健杂志, 2011, 14(4): 360-364. DOI: 10.3969/J.issn.1672-6790.2011.04.009 |
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| 作者姓名： | 高敏 邹延峰 冯晓亮 潘发明 苏虹 范引光 王静 张承业 叶冬青 |
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| 作者单位： | 安徽医科大学公共卫生学院流行病与卫生统计学系,合肥,230032 |
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| 基金项目： | 国家自然科学基金重点项目 |
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| 摘 要： | 目的对白细胞介素(IL)6基因多态性与亚洲人冠心病的关联性进行Meta分析。方法检索PubMed、Elsevier Science Direct、Cochrane Library、中国生物医学文献数据库、万方数据库和中国期刊全文数据库,收集探讨IL-6基因多态性与冠心病关联性的病例对照研究,剔除不符合要求的研究,应用RevMan4.2软件进行Meta分析。结果共11个研究(1821例病例和2453例对照)符合纳入标准。11个研究包括8个在中国,1个在韩国,1个在日本和1个在印度。IL-6基因三个多态性(-572C/G,-174G/C和-634C/G)适合进行Meta分析。Meta分析结果显示在亚洲人中-572C/G多态性和冠心病之间存在关联(GvsC,P=0.00;CG+GGvsCC,P<0.01;GGvsCC+CG,P=0.00;GGvsCC,P=0.00;CGvsCC,P<0.01)。对于-634C/G多态性,Meta分析也显示了类似的关联(GvsC,P=0.01;CG+GGvsCC,P=0.24;GGvsCC+CG,P=0.00;GGvsCC,P=0.00;CGvsCC,P=0.83)。但在亚洲人中-174G/C多态性和冠心病之间无关联(P>0.05)。结论亚洲人中IL-6基因-572C/G和-634C/G多态性与冠心病之间存在关联,而-174G/C多态性和冠心病之间无关联。
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| 关 键 词： | 冠心病 白细胞介素6 多态现象,遗传 Meta分析 |
Association of interleukin-6 gene polymorphisms with susceptibility to coronary heart disease: A meta-analysis |
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| GAO Min,ZOU Yan-feng,FENG Xiao-liang,PAN Fa-ming,SU Hong,FAN Yin-guang,WANG Jing,ZHANG Cheng-ye,YE Dong-qing. Association of interleukin-6 gene polymorphisms with susceptibility to coronary heart disease: A meta-analysis[J]. Chinese Journal of Clinical Healthcare, 2011, 14(4): 360-364. DOI: 10.3969/J.issn.1672-6790.2011.04.009 |
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| Authors: | GAO Min ZOU Yan-feng FENG Xiao-liang PAN Fa-ming SU Hong FAN Yin-guang WANG Jing ZHANG Cheng-ye YE Dong-qing |
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| Affiliation: | GAO Min,ZOU Yan-feng,FENG Xiao-liang,PAN Fa-ming,SU Hong,FAN Yin-guang,WANG Jing,ZHANG Cheng-ye,YE Dong-qing(Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230032,China) |
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| Abstract: | Objective To quantitatively summarize the association of interleukin-6 gene polymorphisms with coronary heart disease using meta-analysis.Methods We surveyed studies on the association of interleukin-6 gene polymorphisms with coronary heart disease in Pubmed,Elsevier Science Direct,Cochrane Library,Chinese Biomedical Literature Database,Wanfang and China National Knowledge Infrastructure.All articles were strictly evaluated and screened according to inclusion criteria,and meta-analysis were perfomed for the... |
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| Keywords: | Coronary diseaseInterleukin-6 Polymorphism genetic Meta-analysis |
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