| 慢性硬膜下血肿液中VEGF、D-二聚体的测定及意义 |
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| 引用本文： | 任东坡,蔺志清.慢性硬膜下血肿液中VEGF、D-二聚体的测定及意义[J].临床神经外科杂志,2011,8(4):195-196. |
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| 作者姓名： | 任东坡 蔺志清 |
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| 作者单位： | 宁波市第一医院神经外科,315000 |
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| 摘 要： | 目的 探讨血肿液中血管内皮生长因子(VEGF)、D-二聚体的含量与慢性硬膜下血肿(CSDH)发生发展的关系.方法 利用酶联免疫吸附分析法(ELISA)及免疫散射比浊法对CSDH 患者血肿液和血清中VEGF、D-二聚体的含量进行测定.结果 血肿液中VEGF、D-二聚体的含量明显高于血清中的含量(P ＜0.001).结论 VEGF、D-二聚体在慢性硬膜下血肿的发病机制中起重要作用.
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| 关 键 词： | 血管内皮生长因子 D-二聚体 慢性硬膜下血肿 |
Assay of VEGF and D-dimer and their Significance in Chronic Subdural Hematoma |
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| REN Dong-po,LIN Zhi-qing.Assay of VEGF and D-dimer and their Significance in Chronic Subdural Hematoma[J].Journal of Clinical Neurosurgery,2011,8(4):195-196. |
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| Authors: | REN Dong-po LIN Zhi-qing |
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| Institution: | .( Department of Neurosurgery, Ningbo First Hospital, Ningbo 315000, China) |
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| Abstract: | Objective To investigate the role of vascular endothelial growth factor （VEGF） and D-dimer in the pathogenesis of chronic subdural hematoma（CSDH）. Methods The concentrations of VEGF and D-dimer in hematoma fluid and serum in patients with CSDH were detected by enzyme 1 inked immunosorbent assay （ELISA） and immunoassay. Results The concentrations of VEGF and D-direct in the hematoma fluid were significantly increased compared with that in the serum （P 〈 0.001 ）. Conclusion VEGF and D-direct may play an important role in the pathogenesis of CSDH. |
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| Keywords: | vascular endothelial growth factor D-dimer chronic subdural hematoma |
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