Hemodynamic effects of hypothyroidism induced by methimazole in normal and portal hypertensive rats |
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Authors: | Ran Oren MD Nir Hilzenrat MD Yoram Maaravi MD Arie Yaari MSc Dr Emanuel Sikuler MD |
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Institution: | (1) Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem;(2) Hepatic Hemodynamic Laboratory, Department of Medicine, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel;(3) Department of Medicine B', Soroka Medical Center, POB 151, 84101 Beer-Sheva, Israel |
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Abstract: | Portal hypertension is accompanied by a hyperdynamic circulatory state that shares some similarities with thyrotoxicosis. This study was conducted in order to investigate the hemodynamic effects of hypothyroidism in a rat model with portal hypertension induced by partial portal vein ligation (PVL). Four groups of 10 rats each were studied: normal control and hypothyroid rats, and PVL control and hypothyroid rats. Hypothyroidism was induced by methimazole 0.04% in drinking water. Hemodynamic measurements were performed using the radioactive microsphere technique. Induction of hypothyroidism was confirmed by elevated TSH levels. In the PVL groups, hypothyroidism ameliorated the hyperdynamic circulation. Portal venous inflow and portal pressure dropped significantly: 7.1±0.2 vs 4.8±0.3 ml/min/100 g body wt (P<0.01) and 13.4±0.9 vs 10.9±0.8 mm Hg; (P<0.01), respectively. In normal rats, hypothyroidism was manifested by a hypodynamic circulatory state. These results demonstrate that hypothyroidism induced by methimazole is followed by amelioration of the hyperdynamic circulation, normalization of portal venous inflow, and reduction of portal pressure. |
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Keywords: | portal hypertension hypothyroidism hemodynamics methimazole portal vein ligation |
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