| Shh在血管瘤中的表达及意义 |
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| 引用本文： | 伍尚敏,洪晓娅,王凌冰,杨婷婷,陈明,王惠,左万昌. Shh在血管瘤中的表达及意义[J]. 昆明医学院学报, 2012, 33(8): 14-16,26 |
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| 作者姓名： | 伍尚敏 洪晓娅 王凌冰 杨婷婷 陈明 王惠 左万昌 |
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| 作者单位： | 1. 昆明医科大学附属甘美医院整形美容科,云南昆明,650011
2. 昆明医科大学第二附属医院整形科,云南昆明,650031 |
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| 基金项目： | 云南省教育厅科学研究基金资助项目(2010C098) |
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| 摘 要： | 目的 测定音猬因子(sonic hedgehog,Shh)在血管瘤内皮细胞(Hemangioma endothelial cells,HEC)和脐静脉内皮细胞(Human umbilical vein endothelial cells,HUVEC)中的表达,探讨Shh与血管瘤及人脐静脉的关系.方法 采用实时荧光定量PCR方法,对临床收集的18例手术切除的新鲜增生期血管瘤病变标本和18例新鲜脐静脉标本,进行实时荧光定量PCR检测Shh表达水平.结果 Shh表达水平在增生期血管瘤明显升高,与脐静脉比较差异有统计学意义(P＜0.01).结论 Shh可能促进血管瘤的生长,可能对血管瘤的病理发生过程发挥作用,但对脐静脉无作用.
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| 关 键 词： | 血管瘤 Shh 细胞因子 荧光定量PCR |
Expression and Significance of Shh in Hemangioma |
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| WU Shang-min , HONG Xiao-ya , WANG Ling-bing , YANG Ting-ting , CHEN Ming , WANG Hui , ZUO Wan-chang. Expression and Significance of Shh in Hemangioma[J]. Journal of Kunming Medical College, 2012, 33(8): 14-16,26 |
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| Authors: | WU Shang-min HONG Xiao-ya WANG Ling-bing YANG Ting-ting CHEN Ming WANG Hui ZUO Wan-chang |
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| Affiliation: | 1)(1) Dept.of Plastic Surgery,The Affiliated Calmette Hospital of Kunming Medical University,Kunming Yunnan 650101;2) Dept.of Plastic Surgery,The 2nd Hospital of Kunming Medical University,Kunming Yunnan 650031,China) |
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| Abstract: | Objective To explore expression of Shh in hemangioma endothelial cells and Human umbilical vein endothelial cells,so as to find out the relationship between Shh and hemangioma and Human umbilical vein.Methods Fresh operative specimens were collected(18 hemangiomas in the proliferating phase and 18 ones were from Human umbilical vein) and were divided into 2 groups: hemangioma and Human umbilical vein.The expression of Shh was detected by PCR(real-time fluorescent quantitate polymerase chain reaction) method.Result The level of Shh expression in proliferating HEC(hemangioma endothelial cells) was higher than that in HUVEC(Human umbilical vein endothelial cells)(P<0.01).Conclusion Shh may promote the growth of hemangioma and has effect on the proliferation of hemangioma,but has no such effect on human umbilical vein. |
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| Keywords: | Hemangioma Shh Cytokine Real-time fluorescent quantitate polymerase chain reaction |
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