乳腺X线致密度与激素受体和人表皮生长因子受体2的相关性探讨

目的探讨乳腺X线致密度与乳腺癌中雌激素受体、孕激素受体及人表皮生长因子受体2之间是否具有相关性。方法回顾性收集了615例经手术证实的原发性乳腺癌患者。就诊时均行乳腺X线摄影,并根据美国放射学会制定的乳腺影像报告及数据系统(BI-RADS)对乳腺X线致密度进行分型。所有病例术后或穿刺后标本均行免疫组织化学染色检测雌激素受体、孕激素受体及人表皮生长因子受体2表达水平,并分析乳腺X线致密度与激素受体、HER2表达及年龄因素之间的相关性。结果乳腺X线致密度随年龄增长逐渐由高向低过渡(r=-0.529,P<0.001)。乳腺X线致密度与孕激素受体表达呈正相关(r=0.099,P=0.014<0.05),与雌激素受体(r=0.016,P=0.699>0.05)及人表皮生长因子受体2表达(r=0.077,P=0.057>0.05)未见明显相关性。结论乳腺X线致密度与乳腺癌孕激素受体表达呈正相关,与患者发病年龄呈负相关。

Research between mammographic breast density and expression status of ER.PR and HER2 in breast cancer

Objective To evaluate the relationship between mammographic density and estrogen receptor（ER）,progesterone receptor（PR） and human epidermal growth factor 2（HER2） status in breast cancer.Methods 615 cases of primary breast cancer confirmed by pathology were retrospectively collected.All the patients had undergone mammography,and the mammographic densities were classified into four types according the breast imaging report and data system（BI-RADS）.ER,PR and HER2 status of breast cancer were measured by immunohistochemistry.Differences between mammographic density and ER,PR and HER2 were statistically analysed.Results Mammographic density turns from high density into low density gradually（r=-0.529,P0.001）.Mammographic density was positive correlated with PR status in breast cancer（r=0.099,P=0.0140.05）,and no statistic relationship was found between mammographic density and ER（r=0.016,P=0.6990.05） or HER2（r=0.077,P=0.0570.05）in breast cancer.Conclusion Mammographic density was positive correlated with PR status in breast cancer,and was negative correlated with age.