超声心动图评价氨氯地平对左室重构及心功能干预作用的研究

目的 应用超声心动图技术评价氨氯地平对原发性高血压左室肥厚(LVH)及心脏功能的干预作用.方法 将120例原发性高血压LVH患者随机分为A、B两组,A组(n=60)予以氨氯地平治疗,B组(n=60)予以贝那普利治疗.疗程6个月.两组在入选前4～6周末服用降压药物,观察治疗过程中患者血压变化及药物不良反应,并且应用超声心动图测定治疗前后心脏形态及功能指标.结果 与用药前比较,A、B两组患者治疗后左室质量指数均下降,E峰,E/A比值、左室射血分数(LVEF)均升高,A峰均降低(P＜0.05);A组患者LVEF的改善程度优于B组( P＜0.05).结论 氨氯地平具有较好的降压、逆转左室肥厚并且改善心脏功能的作用.

Echocardiographic assessment for the reverse effect of amlodipine on left ventricular remodeling and cardiac function

Objective To evaluate the effects of amlodipine on left ventricular hypertrophy(LVH) and cardiac function assessed by echocardiography in patients with essential hypertension.Methods A total number of 120 hypertensive patients with LVH were randomly assigned to two regimens for 6 months: Group A(n=60) were treated with amlodipine,while Group B(n=60) with benazepril.Both groups had not taken any antihypertensive agents for at least 4~6 weeks.Blood pressures and adverse reaction during treatment were recorded.Echocardiography was applied to assess the morphological and functional changes of heart before and after 6-month treatment.Results Compared with those before treatment,the LVMI in both groups decreased significantly and the E peak,E/A ratio and LVEF increased significantly after treatment(P<0.05).The LVEF in group A increased more notably than that in group B(P<0.05).Conclusion Amlodipine can effectively lower blood pressures,reverse LVH and improve cardiac function.