| 芝麻素对肾性高血压大鼠重要脏器中NO含量的影响 |
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| 引用本文： | 郭莉群,孔祥,李先伟,杨解人.芝麻素对肾性高血压大鼠重要脏器中NO含量的影响[J].皖南医学院学报,2006,25(4):248-250. |
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| 作者姓名： | 郭莉群 孔祥 李先伟 杨解人 |
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| 作者单位： | 皖南医学院,药理学教研室,安徽,芜湖,241001 |
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| 基金项目： | 福建省自然科学基金;安徽省教育厅自然科学基金 |
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| 摘 要： | 目的:观察芝麻素对肾性高血压大鼠(RHR)靶器官脏器系数和NO含量的变化。方法:复制两肾一夹型(2KIC)肾性高血压大鼠模型,将造模成功的RHR随机分为5组,每组7只,给药6周后,计算大鼠心、肝、脑、肾靶器官脏器系数并用硝酸还原酶法测定各器官一氧化氮(NO)含量。结果:芝麻素100 mg/(kg.d)]可明显降低心脏和肾脏系数及升高心、肝和肾中NO含量。结论:芝麻素对肾性高血压大鼠靶器官具有一定的保护作用。
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| 关 键 词： | 芝麻素 肾性高血压 脏器系数 NO 大鼠 |
| 文章编号： | 1002-0217(2006)04-0248-03 |
| 收稿时间： | 2006-03-07 |
| 修稿时间： | 2006年3月7日 |
Effects of sesamin on nitric oxide contents in vital organs of renal hypertensive rats |
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| GUO Li-qun,KONG Xiang,LI Xian-wei,YANG Jie-ren.Effects of sesamin on nitric oxide contents in vital organs of renal hypertensive rats[J].Acta Academiae Medicinae Wannan,2006,25(4):248-250. |
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| Authors: | GUO Li-qun KONG Xiang LI Xian-wei YANG Jie-ren |
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| Abstract: | Objective:To investigate the effects of sesamin on organ relative weight and the change of nitric oxide in vital organs of renal hypertensive rats(RHRs).Methods: RHRs induced by 2K1C were divided into 5 groups randomly with 7 rats in each.After six weeks of treatment,proportion of target organs and concentration of nitric oxide(NO) were measured in heart tissues,liver,brain and kidney,respectively.(Results:) Sesamin(100 mg/kg/d,P.O.) could depress the relative weight of heart and kidney or increase the contents of NO in heart,liver and kidney.Conclusion: It suggests that sesamin can protect target organs in renal hypertensive rats. |
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| Keywords: | NO |
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