| 胃转流手术治疗2型糖尿病机制的研究进展 |
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| 引用本文： | 李旭忠,胡 承,张学利. 胃转流手术治疗2型糖尿病机制的研究进展[J]. 中华老年多器官疾病杂志, 2014, 13(8): 628-632 |
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| 作者姓名： | 李旭忠 胡 承 张学利 |
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| 作者单位： | [1]苏州大学医学院,苏州215000; [2]上海交通大学附属第六人民医院内分泌与代谢科,上海市糖尿病研究所,上海200233; [3]上海市奉贤区中心医院普外科,201400 |
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| 基金项目： | 国家自然科学基金（81322010） |
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| 摘 要： | 外科手术已被认可为治疗2型糖尿病（T2DM）的一种新型方式，其中胃转流术是目前备受关注的手术方式，并逐渐进入临床。胃转流术治疗T2DM效果显著，尤其适用于伴肥胖的T2DM患者，甚至可以达到有效控制血糖及缓解糖尿病并发症的目的。然而，其潜在作用机制复杂，主要包括胃肠激素分泌的变化、脂肪因子的作用、胆汁酸代谢等。
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| 关 键 词： | 胃转流术 糖尿病,2型 |
Research progress of the mechanism of gastric bypass in the treatment of type 2 diabetes mellitus |
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| LI Xu-Zhong,HU Cheng,ZHANG Xue-Li. Research progress of the mechanism of gastric bypass in the treatment of type 2 diabetes mellitus[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2014, 13(8): 628-632 |
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| Authors: | LI Xu-Zhong HU Cheng ZHANG Xue-Li |
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| Affiliation: | LI Xu-Zhong, HU Cheng, ZHANG Xue-Li (1Medical College, Soochow University, Suzhou 215000, China; 2Department of Endocrinology and Metabolism, Shanghai Institute of Diabetes, the 6th People＇s Hospital, Shanghai Jiaotong University, Shanghai 200233, China; 3Department of General Surgery, Central Hospital of Shanghai Fengxian District, Shanghai 201400, China) |
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| Abstract: | Surgery has beenaccepted as a newapproach for the treatment of type 2 diabetes mellitus （T2DM）.At present,gastric bypass is thehigh-profileoperation methodandgradually appliedclinically. It showed significant effect in the treatment ofT2DM, especially for the T2DM patients accompanied with obesityandeven achieve the purposeto control blood glucose and its complications.However, the underlying mechanism of gastric bypass in treatingT2DM isquitecomplex, including the changesin gastrointestinal hormones, the action of fat factor,bile acid metabolism,etc. |
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| Keywords: | gastric bypass surgery diabetes mellitus, type 2 |
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