Detection of tubercule antigen in cerebrospinal fluids by ELISA for diagnosis of tuberculous meningitis |
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Authors: | Neelam Wagle Avinash Vaidya Shubhada Joshi S. M. Merchant |
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Affiliation: | (1) Microbiology Section, Aditya Pediatric Research Laboratory, Bai Jerbai Wadia Hospital for Children, 400012 Parel, Bombay |
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Abstract: | An Enzyme Linked Immunosorbent Assay (ELISA) was standardised to detect the presence of tubercule antigen in cerebrospinal fluids from patients with meningitis. CSF samples from clinically suspected cases of tuberculous meningitis, culture proven pyogenic meningitis and non-bacterial aseptic central nervous system (CNS) disorders were tested by ELISA to demonstrate its potential utility for routine diagnostic purpose. Tubercule antigen was detected in 73% cases of tuberculous meningitis and was absent in pyogenic and other non-bacterial CNS disorder cases. The test appears to be a promising approach for a definitive diagnosis of tuberculous meningitis. |
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Keywords: | TB Meningitis Tubercule Antigen ELISA |
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