S-100 protein-positive dendritic cells and CD34-positive dendritic interstitial cells in palatine tonsils |
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Authors: | Theodoros Papadas A Batistatou Panagiota Ravazoula Vassiliki Zolota Panos Goumas |
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Institution: | (1) Sissini 33, 262 24 Patras, Greece e-mail: doulis@pat.forthnet.gr, GR;(2) Department of Pathology, University of Patras Medical School, Regional University of Patras, Patras, Greece, GR;(3) Department of Oto-Rhino-Laryngology, University of Patras Medical School, Regional University of Patras, Patras, Greece, GR |
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Abstract: | Dendritic cells (DCs) are effective antigen-presenting cells and have been shown to mature from precursor CD34-positive stromal
cells (dendritic interstitial cells, DICs) or monocytes. To gain insight into the local immune response in human tonsils,
we investigated immunohistochemically the presence of DCs and DICs in 17 non-hyperplastic and 13 hyperplastic tonsils. Dense
infiltrates of S-100-positive DCs were noted in the majority of hyperplastic tonsils, while there were fewer in non-hyperplastic
tonsils. DICs were noted specifically at the periphery in the dense hemi-capsule cap that separates the tonsil from the underlying
muscle. In addition, their small number suggests that the accumulation of S-100 dendritic cells in hyperplastic palatine tonsils
is achieved through migration from other sites rather than through maturation from precursors locally.
Received: 19 December 2000 / Accepted: 10 April 2001 |
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Keywords: | Dendritic cells Dendritic interstitial cells Palatine tonsils |
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