1型糖尿病患儿血清IL-17水平变化及维生素A对其的影响

[摘要]目的：探讨1型糖尿病（T1DM）患儿血清白细胞介素-17（IL-17）水平的变化及维生素A对其的调节作用。方法：选取54例来我院就诊的T1DM患儿，随机分为未干预组29例和维生素A干预组25例，两组均予以常规糖尿病综合治疗，维生素A干预组每日服用维生素A 2 000 U，分别于干预前、干预后3个月留取血清-80 ℃保存，检测患儿血清IL-17及维生素A水平，并与同期于儿童保健科健康体检的28例健康儿童进行对照。结果：未干预组和维生素A干预组IL-17水平均明显高于对照组（P<0.01），血清维生素A水平均明显低于对照组（均P<0.01）。维生素A干预组干预后3个月的血清IL-17水平均低于干预前（P<0.01）；未干预组治疗前后的血清IL-17水平比较差异无统计学意义（t=1.42，P>0.05）。结论：T1DM患儿血清IL-17水平明显升高，维生素A干预可以降低T1DM患儿血清IL-17水平。

Changes of Serum Interleukin-17 Levels and Effects of Vitamin A in Children with Type 1 Diabetes Mellitus

[Abstract] Objective: To probe into the changes of serum interleukin-17 (IL-17) levels and effects of vitamin A in children with type 1 diabetes mellitus (T1DM). Methods: Totally 54 children with T1DM were extracted to be divided into the non-intervention group (n=29) and the vitamin A intervention group (n=25). Both groups were given routine comprehensive treatment of diabetes, and the children in vitamin A intervention group received a daily dose of 20 000 IU vitamin A, the serum was respectively stored at -80 °C before intervention and 3 months after intervention, and the serum IL-17 and vitamin A levels were measured. The results were compared with those of 28 healthy children who underwent physical examination in the department of child health during the same period. Results: The IL-17 levels in the non-intervention group and the vitamin A intervention group were significantly higher than those in the control group (P<0.01), and the serum vitamin A levels were significantly lower than those in the control group (P<0.01). The serum IL-17 levels in vitamin A intervention group after 3 months of intervention were significantly lower than those before intervention (P<0.01). There was no significant difference in serum IL-17 levels in non-intervention group before and after treatment (t=1.42, P>0.05). Conclusion: The serum IL-17 levels increased significantly in children with T1DM, and vitamin A intervention can reduce the serum IL-17 levels in children with T1DM.