| 奎的平与氯氮平治疗复发性精神分裂症对照研究 |
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| 引用本文： | 唐振坤 徐春梅 陈德彩 陈立亮 管銮友 陈明晓. 奎的平与氯氮平治疗复发性精神分裂症对照研究[J]. 精神医学杂志, 2005, 18(3): 167-168 |
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| 作者姓名： | 唐振坤 徐春梅 陈德彩 陈立亮 管銮友 陈明晓 |
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| 作者单位： | 山东省临沂市精神卫生中心 276005(唐振坤，徐春梅，陈德彩，陈立亮，管銮友)，山东省临沂市精神卫生中心 276005(陈明晓) |
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| 摘 要： | 目的对比奎的平与氯氮平治疗复发性精神分裂症的疗效和安全性。方法分别以奎的平与氯氮平治疗复发性精神分裂症36例，采用阳性症状与阴性症状量表(PANSS)、副反应量表(TESS)在治疗前及治疗后第1、2、4、6、8周末分别评定疗效及不良反应。结果奎的平有效率77．8％，显效率61．1％；氯氮平有效率75％，显效率58．3％，两药的疗效相当；两组治疗后与治疗前的PANSS评分比较差异均有显著性，奎的平不良反应少于氯氮平。结论奎的平治疗复发性精神分裂症疗效较好，不良反应较氯氮平轻，病人服药依从性好。
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| 关 键 词： | 精神分裂症 奎的平 氯氮平 |
| 文章编号： | 1009-7201(2005)-03-0167-02 |
| 修稿时间： | 2004-08-14 |
A comparative study of quetiapine and clozapine in the treatment of recurrent schizophrenia |
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| TANG Zhen-kun,XU Chun-mei,CHEN De-cai,et al.. A comparative study of quetiapine and clozapine in the treatment of recurrent schizophrenia[J]. Journal of Psychiatry, 2005, 18(3): 167-168 |
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| Authors: | TANG Zhen-kun XU Chun-mei CHEN De-cai et al. |
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| Affiliation: | TANG Zhen-kun,XU Chun-mei,CHEN De-cai,et al.Lin Yi Mental Health Center,Shandong 276005,China |
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| Abstract: | Objective To compare the efficacy and safety between quetiapine and clozapine in the treatment of recurrent schizophrenia. Methods Thirty-six recurrent schizophrenic patients were treated with quetiapine and thirty-six patients with clozapine.The efficacy was assessed with the Positive And Negative Symptoms Scale(PANSS),and the side effects with the Treatment Emergent Symptom Scale(TESS).Results The effective rate and marked improvement rate in quetiapine were 77.8% and 61.1%,and these rates in clozapine were 75% and 59%.There were no differences between two groups.The PANSS scores in both groups decreased significantly after treatment.Quetiapine had fewer side effects than clozapine.Conclusion Quetiapine has good efficacy,high safety,few side effects and good compliance in treating schizophrenia. |
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| Keywords: | Schizophenia Quetiapine Clozapine |
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