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Action of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) against untreated human ovarian cancers in the murine xenograft assay |
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| Authors: | J P Micha P R Kucera C U Preve M A Rettenmaier J A Stratton P J DiSaia |
| Affiliation: | 1. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of California, Irvine Medical Center, 101 The City Drive, Building 25, Orange, California 92668 U.S.A.;2. Division of Pathologic Obstetrics and Gynecology, University of Turin, Via Ventimiglia-3, Turin, Italy |
| Abstract: | The activity of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) was determined in nine untreated human ovarian cancer specimens, using the murine subrenal capsule xenograft assay. Tumor cytotoxic effect was demonstrated in seven out of the nine tumors implanted. The drug was well tolerated by the test animals. Tiazofurin may prove to be an effective chemotherapeutic agent in the treatment of ovarian cancer. |
| Keywords: | To whom reprint requests should be addressed at Hoag Hospital Cancer Center 400 Newport Center Drive Newport Beach Calif. 92660. |
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