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住院肺结核病人对氧氟沙星耐药情况分析
引用本文:谭云洪. 住院肺结核病人对氧氟沙星耐药情况分析[J]. 实用预防医学, 2003, 10(5): 655-657
作者姓名:谭云洪
作者单位:湖南省结核病防治所,中国湖南,长沙,410006
摘    要:目的 了解住院肺结核病人对氧氟沙星的耐药性,从而探讨氧氟沙星作为耐多药结核病首选药物的可行性。方法 对2000年3月~2002年12月期间的住院肺结核病人有抗结核药物敏感试验结果者140例进行氧氟沙星耐药性的回顾性调查。结果 曾使用氟喹诺酮类药物者治疗者23例中,8例对OFLX耐药,继发耐药率为34.78%;既往从未使用过氟喹诺酮类药物117例中,15例耐药,原发耐药率为12.82%。结论 随着临床上越来越多的使用氟喹诺酮类药物,氧氟沙星耐药率有所增高,但相对其他的抗结核药物.氧氟沙星的耐药率较低,仍可作为临床上一个有效的抗结核药物.用于耐多药结核病的治疗是可行的。

关 键 词:肺结核 氧氟沙星 药物敏感试验 耐药性
文章编号:1006-3110(2003)05-0655-03
修稿时间:2003-05-28

The Resistance of ofloxacin(OFLX) in Hospitalized Patients with Pulmonary Tuberclosis
TAN Yunhong. The Resistance of ofloxacin(OFLX) in Hospitalized Patients with Pulmonary Tuberclosis[J]. Practical Preventive Medicine, 2003, 10(5): 655-657
Authors:TAN Yunhong
Abstract:Objective Analyse the resistance of OFLX of in patients with pulmonary tuberculosis to study the feasibility of OFLX that chosen as the first drug to MDR-TB. Methods Retrospectively investigate 140 cases with pulmonary tuberculosis that were sputum culture-positive and possessed drug susceptibility test results from Mar.2000 to Dec.2002. Result The result showed that 8 cases (34.78%)occurred secondary resistance,15cases (12.82%) occurred primary resistance.It is suggested that long term use of anti-TB drug and equivalent to monotherapy with OFLX are the causes of secondary resistance, and infected by OFLX-resistant bacilli or having been used to cure common inflammation may lead to primary resistant. Conclusion Due to it's low resistance rate, OFLX is still an effective anti-tuberculosis drug,though the rate increases lightly.It is feasible to choose OFLX as the first drug to MDR-TB.
Keywords:Pulmonary Tuberculosis  Ofloxacin  Drug susceptibility test
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