Molecular aspects of cholangiocarcinoma |
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| Authors: | Kaoru Kiguchi |
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| Affiliation: | Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA |
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| Abstract: | Novel targets for therapeutic or chemopreventive approaches against cholangiocarcinoma (CCA) are urgently needed. In this review article, we discuss the molecular aspects of CCA including the role of erbB receptor tyrosine kinases (RTKs), downstream signaling pathways of these erbB RTKs, inflammatory mediators during gallbladder carcinogenesis and bile acids based on our study using a mouse model for human CCA (BK5.erbB2 mice) as well as additional information in the literature. |
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| Keywords: | Cholangiocarcinoma COX‐2 and bile acid Epidermal growth factor receptor · erbB2 |
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