Antimicrobial activity of LB10827, a new orally administered cephalosporin, tested against Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae |
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Authors: | L M Deshpande M L Beach A H Mutnick R N Jones |
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Institution: | JMI Laboratories/The JONES Group, 345 Beaver Kreek Center, Suite A, North Liberty, Iowa 52317,; University of Iowa, College of Pharmacy, Iowa;and Tufts University School of Medicine, Boston, Massachusetts, USA; Tel: +1 319 665 3370 Fax: +1 319 665 3371 E-mail: |
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Abstract: | A new orally administered cephalosporin, LB10827, was compared to 16 other antimicrobial agents tested against Streptococcus pneumoniae (520 strains), Haemophilus influenzae (302 strains) and Moraxella catarrhalis (188 strains) by reference broth microdilution methods. LB10827 (MIC90, 0.12 mg/L; highest MIC, 0.5 mg/L) was 8–16-fold more potent than cefdinir, cefpodoxime or cefuroxime when tested against S. pneumoniae . All Gram-negative strains were inhibited at ≤ 0.5 mg/L LB10827, which is an activity equal or superior to that of currently available and tested oral β-lactams. LB10827 appears to be a promising agent worthy of continued investigations both in vitro and in vivo. |
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Keywords: | LB10827 cephalosporins respiratory tract infections Streptococcus pneumoniae |
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