Helvecardins A and B, novel glycopeptide antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical properties |
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| Authors: | M Takeuchi R Enokita T Okazaki T Kagasaki M Inukai |
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| Affiliation: | Fermentation Research Laboratories, Sankyo Co, Ltd., Tokyo, Japan. |
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| Abstract: | A strain of actinomycetes identified as Pseudonocardia compacta subsp. helvetica produced new glycopeptide antibiotics, helvecardins A and B. They were isolated from culture broth mainly by affinity chromatography of D-alanyl-D-alanine and preparative HPLC. The physico-chemical properties of helvecardins A and B showed that they resemble each other. Though helvecardin A was structurally related to beta-avoparcin, it clearly differed in the presence of an O-methyl moiety in its NMR spectrum. |
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