红花液对实验性心肌梗塞犬不同梗塞区心肌缺血程度的影响

由结扎左前降冠状动脉尖支的方法造成犬的心肌梗塞,用心外膜电图标测术评价中药红花提取液对心肌缺血程度的影响。本研究发现,红花液显著减少心外膜电图标测点ST段平均抬高程度,这种变化尤以梗塞边缘区为甚。红花液还可明显减少梗塞边缘区ST段显著抬高的标测点数。输入红花液后,心率及张力—时间指数明显减少。说明红花可以挽救梗塞边缘区濒危缺血心肌而缩小急性冠脉闭塞后的梗塞范围,这种有益作用可能与其降低心肌耗氧量有关。

EFFECT OF HONG-HUA (FLOS CARTHAMI) ON THE EXTENT OF MYOCARDIAL ISCHEMIA IN THE DIFFERENT INFARCT ZONES FOLLOWING CORONARY OCCLUSION IN THE DOG

Myocardial infarct was produced by occluding the apical branch of the left anteriordescending coronary artery. The effect of the corolla extract of Flos Carthami, the Chinese medicinal plant "Hong-Hua", on the extent of myocardial ischemia was evaluated by means of the epicardial electrographic mapping. During the 15 rain-occlusion the mapping was performed in 5 min interval, then the coronary occlusion was released. After reperfusion for 1 hr, while the Hong-Hua extract was being infused, a second occlusion and mapping was applied again as before@Hong-Hua extract (25%) in a dose of 2 g/kg reduced the average ST segment elevation. In the central infarct zone, 15 min after the first and second occlusion were 7.5±0.6 and 3.3±0.5mV respectively (P<0.001), whereas in the border zone the correspoding values of were 3.5±0.4 and 0.9±0.2mV(P<0.001). Reduction of was more Significant in the border zone than in the central zone (P<0.001).@Hong-Hua extract administered during the second occlusion markedly reduced the number of sites showing equal or greater than 2 mV ST segment elevation (NST) in the border zone as compared with occlusion alone, but NST remained unchanged in the central zone.@After administration of Hong-Hua extract, heart rate decreased from initial value of 164±11 to 144±9 beats/min (P<0.05) and tension-time index from 129.0±6.3 to 116.8±6.3 (P<0.01).@Our data suggest that Hong-Hua may reduce the infarct size following acute coronary occlusion by salving a lot of jeopardized myocardium in the border ischemic zone, and that the reduction of myocardial oxygen consumption was involved in the beneficial action of Hong-Hua.