Trophic action of epidermal growth factor on human duodenal mucosa cultured in vitro. |
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| Authors: | D N Challacombe and E E Wheeler |
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| Affiliation: | Somerset Children's Research Unit, Musgrove Park Hospital, Taunton. |
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| Abstract: | The action of epidermal growth factor on the human duodenal mucosa has been studied by estimating the crypt cell production rate in cultured explants, using a stathmokinetic technique with crypt microdissection. The addition of epidermal growth factor (400 ng/ml) to paired explants from five patients caused an almost fivefold increase in the crypt cell production rate, showing that epidermal growth factor has a trophic action on the human duodenal mucosa in vitro. |
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