基于药性组合的归胃经中药的药理作用特征研究

目前中药药性的研究多局限于单一或两类药性层面，偏离了中医药理论体系的整体观念。该文以不同药性组合的归胃经中药的药理作用特征为研究目的。整理2005年版《中国药典》中归胃经中药的药性数据，收集来自中国期刊全文数据库（CNKI）1980年以来的全部文献和《中药学》（颜正华，人民卫生出版社，2006年）、《临床中药学》（高学敏、钟赣生，河北科学技术出版社，2005年）中归胃经中药的药理作用数据，利用关联规则方法，挖掘归胃经中药药性组合所对应的药理作用。所得关联规则结果与经验知识相符，不同的药性组合有各自的药理作用特征，通过比较发现不同药性组合间的药理作用既有差异性也有相似性。药性组合间因为具有相同的四气或五味而表现出相似的药理作用，因为具有不同的四气或五味而具有差异性的药理作用，而四气和五味均不同的药性组合其药理作用也可以表现出相似性。该研究将药性理论与中药药理作用研究成果结合，揭示了归胃经中药的药理作用的主要特征和规律，为揭示归胃经中药的作用机制，发现归胃经中药的药理作用提供了新的思路与方法。

Study on characteristics of pharmacological effects of traditional Chinese medicines distributing along stomach meridian based on medicinal property combination

At present, studies on traditional Chinese medicine(TCM) properties are mostly restricted to a single or two kinds of medicinal properties, but deviated from the holism of the theoretical system of TCMs. In this paper, the characteristics of pharmacological effects of different property combinations of TCMs distributing in the stomach meridian were take as the study objective. The data of properties of TCMs distributing in the stomach meridian was collected from the Pharmacopoeia of the People's Republic of China (2005). The data of pharmacological effects of TCMs distributing in the stomach meridian was collected from all of literatures recorded in Chinese Journal Full-text Database (CNKI) since 1980, Science of Chinese Materia Medica (Yan Zhenghua, People's Medical Publishing House, 2006) and Clinical Science of Chinese Materia Medica (Gao Xuemin, Zhong Gansheng, Hebei Science and Technology Publishing House, 2005). The corresponding pharmacological effects of property combinations of TCMs distributing in the stomach meridian was mined by the method of association rules. The results of the association rules were consistent with the empirical knowledge, and showed that different medicinal property combinations had respective pharmacological characteristics, including differences and similarities in pharmacological effects of different medicinal property combinations. Medicinal property combinations with identical four properties or five tastes showed similar pharmacological effects; whereas medicinal property combinations with different four properties or five tastes showed differentiated pharmacological effects. However, medicinal property combinations with different four properties or five tastes could also show similar pharmacological effects. In this study, the medicinal property theory and the pharmacological effects of TCMs were combined to reveal the main characteristics and regularity of pharmacological effects of TCMs distributing in the stomach meridian and provide a new way of thinking and method for revealing the mechanism action of TCMs distributing in the stomach meridian and discovering the pharmacological effects of TCMs distributing in the stomach meridian.