首页 | 本学科首页   官方微博 | 高级检索  
检索        

TRPV1离子通道与中药辛味药性的关系研究
引用本文:王星,张燕玲,王耘,任真真,鲍红娟,乔延江.TRPV1离子通道与中药辛味药性的关系研究[J].中国中药杂志,2014,39(13):2422-2427.
作者姓名:王星  张燕玲  王耘  任真真  鲍红娟  乔延江
作者单位:北京中医药大学 中药信息工程研究中心, 北京 100102;北京中医药大学 中药信息工程研究中心, 北京 100102;北京中医药大学 中药信息工程研究中心, 北京 100102;北京中医药大学 中药信息工程研究中心, 北京 100102;厦门医学高等专科学校 福建省中药精加工及健康产品开发重点研究室, 福建 厦门 361008;北京中医药大学 中药信息工程研究中心, 北京 100102
基金项目:国家科技支撑计划项目(2008BAI51B01);国家自然科学基金项目(81173522);北京中医药大学自主选题项目(2013-JYBZZ-XS-118)
摘    要:中药五味理论及味效发生机制一直是中药药性研究领域的重点和难点。该文利用基于药效团的虚拟筛选技术,通过研究中药成分对TRPV1离子通道的调节作用探讨TRPV1与中药辛味药性之间的关系。结果发现TRPV1激动剂药效团模型与中药化学成分之间的匹配关系揭示了辛味中药的药效成分。因此,提出TRPV1离子通道是辛味药性发挥药效的潜在靶点之一。中药辛味药性是由其化学成分决定的,且在不同层次上符合继承性和加和性等特点。

关 键 词:TRPV1离子通道  辛味药性  药效团  虚拟筛选
收稿时间:2013/11/27 0:00:00

Study on relations between transient receptor potential vanilloid 1 and pungent property of traditional Chinese medicines
WANG Xing,ZHANG Yan-ling,WANG Yun,REN Zhen-zhen,BAO Hong-juan and QIAO Yan-jiang.Study on relations between transient receptor potential vanilloid 1 and pungent property of traditional Chinese medicines[J].China Journal of Chinese Materia Medica,2014,39(13):2422-2427.
Authors:WANG Xing  ZHANG Yan-ling  WANG Yun  REN Zhen-zhen  BAO Hong-juan and QIAO Yan-jiang
Institution:Information Engineering Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China;Information Engineering Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China;Information Engineering Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China;Information Engineering Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China;Key Laboratory of Traditional Chinese Medicine Finish Processing and Health Product Development of Fujian Province, Xiamen Medical College, Xiamen 361008, China;Information Engineering Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China
Abstract:The five-flavor theory of traditional Chinese medicines(TCM) and the flavor efficacy generation mechanism has long been focuses and difficulties in studies on traditional Chinese medicinal properties. In this paper, by using the pharmacophore-based virtual screening technique, the authors discussed the relations between the pungent property and transient receptor potential vanilloid 1 (TRPV1) by studying the TCM components' role in regulating TRPV1 ion channel. The results showed that the matching relationship between TRPV1 agonist pharmacophore model and TCM chemical components could identify the active ingredients from pungent herbs. Therefore, the authors proposed that TRPV1 is one of the potential targets for efficient pungent herbs. The pungent property of TCMs is decided by its chemical components, and consistent with the inherited and additive characteristics.
Keywords:TRPV1 ion channel  pungent property  pharmacophore  virtual screening
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号