| Abstract: | Experiments with heterologous rabbit antifibroblast sera (AFS) against guinea pig stromal mechanocytes showed that culture media from subcultured stromal mechanocytes from the bone marrow, spleen, and thymus contain a specific trypsin-resistant fibroblast protein (AG-1), which is present also in normal blood serum and on the surface of the stromal fibroblasts. AG-1 is insensitive to the action of collagenase and evidently differs from the chief surface protein (CSP) of fibroblasts. AG-1 is a  1-globulin and is probably the hitherto unknown specific surface protein of fibroblasts. Antibodies against a nonspecific fibroblast protein (AG-2) and an  1-globulin related to AG-1 also were found in the AFS.Laboratory of Immunomorphology, N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR P. A. Vershilova.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 10, pp. 454–458, October, 1978. |
